Given the linear model
yy=Xββ+ϵϵ
One of the assumption that must be satisfied to recover an unbiased estimate of ββ is that
E[ϵi∣xxi]=0
That is to say, given our prediction some xxi we would have no better guess for ϵi other than 0.
This condition implies that Cov(xxi,ϵi)=00.